Protein Activity Detection

Cut - N - Glow™

Successful detection of Protein Activity

Specific proteases or protease inhibitors or

mapping protease substrate preference in vitro

Cut-N-Glow™  is the first fully biological in vivo protease mapping tool that emits fluorescence. This assay is easily tailored via standard cloning techniques to detect specific proteases or protease inhibitors or to map protease substrate preference in vitro or in vivo. Chemical synthesis is not required and there is no need for co-factors or co-substrates. Additionally, this assay only requires two reagents and both are proteins that can be easily obtained following over-expression of E. coli.

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  1. Cut - N - Glow™ HIV Protease Activity Kits (sku=26004001)

    $395.00

    Kit Contains Sufficient Product to Perform 96 Tests

    The Cut-N-Glow assay kit allows for detection of specific proteases or protease inhibitors or mapping protease substrate preference in vitro or in vivo using split GFP technology.

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  2. Cut - N - Glow™ Caspase-3 Activity Kit (CASP-3) (sku=27004001)

    $395.00

    CASP-3 is a member of the Caspase family (cysteine-aspartic acid protease) and when activated, is an essential factor in cell apoptosis.

    Kit Contains Sufficient Product to Perform 96 Tests

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  3. Cut-N-Glow™ Enteropeptidase Activity Kit (sku=30004001)

    $395.00

    Enteropeptidase is a serine protease produced by cells of the duodenum and is involved in human digestion. This enzyme is a serine protease that is secreted from intestinal gland following the entry of ingested food passing from the stomach. Enteropeptidase is a part of the chymotrypsin-family of serine proteases, and cleaves trypsinogen and produces active trypsin, thereby leading to the activation of many pancreatic digestive enzymes.

     

     This assay kit is specific for Enteropeptidase activity and contains sufficient reagents for one 96-well plate (96 tests)

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  4. Cut-N-Glow™ Factor X Activity Kit (Factor Xa) (sku=29004001)

    $395.00

    Factor X, or prothrombinase, is a serine endopeptidase of the coagulation cascade. Factor X is activated into factor Xa, which functions to cleave prothrombin to yield thrombin. Thrombin acts as a serine protease that catalyzes the conversion of soluble fibrinogen into insoluble strands of fibrin, in addition to catalyzing many other coagulation-related reactions., or prothrombinase, is a serine endopeptidase of the coagulation cascade. Factor X is activated into factor Xa, which functions to cleave prothrombin to yield thrombin. Thrombin acts as a serine protease that catalyzes the conversion of soluble fibrinogen into insoluble strands of fibrin, in addition to catalyzing many other coagulation-related reactions.

     

     This assay kit is specific for Factor Xa activity and contains sufficient reagents for one 96-well plate (96 tests)

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  5. Cut-N-Glow™ Thrombin Activity Kit (sku=28004001)

    $395.00

    Thrombin is a multi-functional protein, derived from the proteolytic cleavage of prothrombin, and is essential to the coagulation cascade allowing blood to clot. Thrombin acts as a serine protease that catalyzes the conversion of soluble fibrinogen into insoluble strands of fibrin , in addition to catalyzing many other coagulation-related reactions.

    Kit Contains Sufficient Product to Perform 96 Tests

     

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