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nti-EGFR FluorAbody binds region on domain III of EGFR distinct from ligand-binding region as well as cetuximab/Erbitux epitope. It also sterically blocks domain rearrangement, receptor activation, and dimerization. It is monovalent and will bind only one region on domain III of EGFR and thus allows stoichiometric quantitation of the antigen in vitro. It can be imaged on a properly equipped fluorescent microscope as well as detected in a flow cytometer or other fluorometric system. At 51-54 kD it is roughly 1/3 the size of an IgG antibody making it less likely to cause steric hindrance. Due to being recombinant and intrinsically fluorescent, each antibody lot is identical to the next, eliminating the necessity for re-titration.

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SKU 31004002
Binding Domain anti-EGFR

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