Fluorescent G-1 (FLG-1)  Estrogen Receptor Ligand

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Fluorescent Analog of G-1 (FLG-1)

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$285.00

G-1 is a cell permeable, nonsteroidal, dihydroquinoline, high-affinity, selective agonist for GPER/GPR30, the transmembrane G protein-coupled estrogen receptor. G-1 competes for estrogen binding to GPER with a Ki value of 11 nM. Competitive binding studies in ERα- and ERβ-expressing cells show little binding of G-1 up to 10 μM. The discovery of G-1, a compound that does not bind classical ERs, has greatly facilitated physiological experiments to define the role of GPER in vivo. FLG-1 is an experimental Fluorescent Analog of G-1 and is not fully characterized.

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$285.00
 
 

FLG-1 (Fluorescent Analog of G-1) is a GPER/GPR30 agonist, G-1, which has been conjugated to fluorescein. FLG-1 was developed to provide research scientists a powerful tool to investigate the GPER, and ultimately lead to the better understanding of the complex physiological and pathological contributions of the GPER. The fluorescent conjugated agonist will provide a means to monitor dynamic processes such as receptor internalization and trafficking. FLG-1 will also allow for the monitoring of physiological responses, while simultaneously providing a means to determine receptor localization and quantification. FLG-1 is a safe and cost effective alternative to the use of radiolabled ligands.

Fluorescent G-1 (FLG-1) will provide research scientists a powerful tool to investigate the G-Protein Coupled Estrogen
Receptor, and ultimately lead to the better understanding of the complex physiological and pathological contributions of
the GPER. The fluorescent conjugated agonist will provide a means to monitor dynamic processes such as receptor
internalization and trafficking. FLG-1 will also allow for the monitoring of physiological responses, while simultaneously
providing a means to determine receptor localization and quantification. FLG-1 is a safe and cost effective alternative to
the potential use of radiolabled ligands. FLG-1 is a Fluorescein conjugated analog of G-1.

 

Download Fluorescent G-1 (FLG-1) PDF

 

Sandia biotech products are intended for research use only and are not to be used for any other purpose, which includes but is
not limited to: unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of
consumption or application to humans or animals. FLG-1 has not been fully tested and Sandia biotech makes not warranties
regarding the performance of the product. Sandia Biotech will update all materials as the organization continues to gain more
information about the performance and applications of FLG-1.

 

Additional Information

SKU 41004002
GPER Agonist

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